Peptide antibiotics--biosynthesis and functions
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Peptide antibiotics--biosynthesis and functions enzymatic formation of bioactive peptides and related compounds by

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Published by W. de Gruyter in Berlin, New York .
Written in English


  • Peptide antibiotics -- Physiological effect.,
  • Peptide antibiotics -- Synthesis.,
  • Microbiological synthesis.

Book details:

Edition Notes

Includes bibliographical references and index.

Statementeditors, Horst Kleinkauf, Hans von Döhren.
ContributionsKleinkauf, Horst, 1930-, Döhren, Hans von, 1948-
LC ClassificationsQP801.A63 P46 1982
The Physical Object
Paginationxi, 479 p. :
Number of Pages479
ID Numbers
Open LibraryOL3482018M
ISBN 103110084848
LC Control Number82001391

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Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): (external link) https Author: D.W. Young. Abstract. Peptide antibiotics are known to contain non-protein amino acids, D-amino acids, hydroxy acids, and other unusual constituents. In addition they may be modified by N-methylation and cyclization biosynthetic origin has been connected in many cases to an enzymatic system referred to as the ‘thiotemplate multienzymic mechanism’.Cited by: 1. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic.   CELL-FREE BIOSYNTHESIS OF PEPTIDE ANTIBIOTICS H. Kleinkauf* and H. v. Döhren* *Institut für Biochemie und Molekulare Biologie, Technische Universität Berlin, Franklinstraße 29, D Ber West-Germany ABSTRACT Secondary metabolites, especially peptide antibiotics,can be produced by soluble multienzyme systems.

However, a larger antibiotic peptide produced by Bacillus subtilis ATCC , subtilin, with 32 amino acid residues, was found to be formed by processing of its precursor protein. There are two different mechanisms for the synthesis of antibiotic oligopeptides by microorganisms. Differential protection and selective deprotection in peptide synthesis is deliberated in Chapter 5. In chapter 6, the opportunities and constraints of the tactics of minimal protection of side-chain functions during peptide synthesis are reviewed. The last chapter is devoted to the interesting aspects of dual function groups.   Although the synthesis and clinical use of the first synthetic peptide, insulin, dates back to s [, ], it had not been possible to consider peptides as potential drugs before the introduction in s by the Nobel Chemistry Prize Laureate Bruce Merrifield, of solid phase peptide synthesis, which lowered the production costs and. Antibacterial peptide CM4 (ABP-CM4) is a small cationic peptide with broad-spectrum activities against bacteria, fungi and tumor cells and may possibly be used as an antimicrobial agent. In this study, a C-terminal amidated antibacterial peptide ABP-CM4 (ABP-CM4N) with the strongest antibacterial activity wa.

  About this book This is the first of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry.   The biosynthesis of the lipopeptide antibiotic surfactin was studied in whole cells of Bacillus subtilis ATCC which incorporate 14 C-labeled precursor amino acids directly into the product. [14 C]Acetate appeared in the fatty acid portion of surfactin and was also partially converted into enzyme was isolated and partially purified from a cell-free extract of the bacillus which. Correlation of bacterial genome size and secondary metabolite production. Donadio et al. () suggested that genomes of ≤3 megabases of DNA would have little capacity for polyketides or nonribosomal peptides beyond siderophores needed for import of iron. It remains to be seen if the correlation holds when tens of thousands of additional bacterial genomes are curated. In book: Peptide antibiotics -biosynthesis and functions, Chapter: Kinetics of amino acid activation in gramicidin S synthesis., Publisher: Walter de Gruyter, Berlin, Editors: H Kleinkauf, H von.